GSNO reductase and β2-adrenergic receptor gene–gene interaction: bronchodilator responsiveness to albuterol
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چکیده
منابع مشابه
Bronchodilator reversibility to albuterol predicts bronchodilator response to salmeterol.
We read with interest the recent study by Fish et al (August 2001)1 showing that adding salmeterol to inhaled corticosteroid achieved superior control as compared to adding montelukast. However it is likely that the results were biased toward the long-acting 2-agonist as patients were required as an inclusion criteria to have at least 12% increase in FEV1 in response to albuterol. It is therefo...
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A third of marketed drugs act by binding to a G-protein-coupled receptor (GPCR) and either triggering or preventing receptor activation. Although recent crystal structures have provided snapshots of both active and inactive functional states of GPCRs, these structures do not reveal the mechanism by which GPCRs transition between these states. Here we propose an activation mechanism for the β(2)...
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ژورنال
عنوان ژورنال: Pharmacogenetics and Genomics
سال: 2010
ISSN: 1744-6872
DOI: 10.1097/fpc.0b013e328337f992